Chronic Fatigue Syndrome (CFS) is a debilitating illness that can have devastating effects for those afflicted, especially children and adolescents. Pediatric Chronic Fatigue Syndrome discusses this growing problem and its many facets in detail, including the mounting prevalence of incidents in the population and detailed explanations of diagnostic criteria. Case studies are provided to illustrate the issues those afflicted with CFS face, such as increasing isolation, decreasing school attendance, the length of time it typically takes to get diagnosed, and the impact on leisure activities. This source includes recommendations developed by the International Association of Chronic Fatigue Syndrome Pediatric Case Definition Working Group and guidelines on ways ME-CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) can be addressed in primary practice.