An Obese Genotype Affects the Apoptosis Related Gene Expressions
by Nafiseh Nafissi (9783639162462)

An Obese Genotype Affects the Apoptosis Related Gene Expressions

Nafiseh Nafissi

Release Date: 01 July 2009
Format: Paperback
Pages: 108
Category: Genetics
Publisher: VDM Verlag
ISBN: 9783639162462
ISBN-10: 3639162463

Apoptosis is a genetically regulated form of cell death that occurs when the cell is exposed to physiological, pathogenic, or cytotoxic stimuli. Unregulated apoptosis at any time from embryogenesis to adulthood can result in a variety of disease states, such as neurodegenerative disorders, autoimmunity, cardiovascular disease, liver and kidney problems, and cancer. A reasonable estimation is that either too little or too much cell death contributes to half of the main medical illnesses for which adequate therapy or prevention is lacking. The apoptotic pathways can be initiated by reactive oxygen species (ROS) and inflammatory molecules, both of which are believed to be up-regulated in a state of obesity. In addition, multiple studies have shown that the risk of developing cardiovascular disease, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and certain types of cancers increase with increasing degree of obesity in both men and women. Despite the well characterized association of obesity and disease incidence, the mechanisms by which obesity contributes to disease pathology are poorly understood.

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