Approaches to the Conformational Analysis of Biophamaceuticals
by Roger L Lundblad (9781439807804)

Approaches to the Conformational Analysis of Biophamaceuticals
 
Roger L Lundblad
Release Date: 15 December 2009
Format: Hardback
Pages: 366
Categories: Biochemistry
Pharmacology
Publisher: Taylor and Francis
ISBN: 9781439807804
ISBN-10: 1439807809



Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book describes methods used to establish comparability between potentially identical products. It provides researchers with a critical description of studies drawn from the current literature. The text covers physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation, as well as chemical methods, including hydrogen-deuterium exchange and trace labeling. The author shows how these methods support comparability claims for generic biologicals and assure structural integrity of active pharmaceutical ingredients in final drug products.

AUD $360.00

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