Blood and Tissue Nitric Oxide Products
by Nathan Bryan (9783639178098)

Blood and Tissue Nitric Oxide Products
Nathan Bryan
Release Date: 01 August 2009
Format: Paperback
Pages: 152
Category: Biochemistry
Publisher: VDM Verlag
ISBN: 9783639178098
ISBN-10: 3639178092

There is mounting evidence that the established paradigm of nitric oxide (NO) biochemistry, from formation through NO synthases, over interaction with soluble guanylyl cyclase, to eventual disposal as nitrite/nitrate, represents only part of a richer chemistry through which NO elicits biological signalling. Additional pathways have been suggested that include interaction of NO-derived metabolites with thiols and metals to form S-nitrosothiols (RSNOs) and metal nitrosyls. Despite the overwhelming attention paid in this regard to RSNOs, little is known about the stability of these species, their significance outside the circulation, and whether other nitros(yl)ation products are of equal importance. Our study further reveals that all NO-derived products are highly dynamic, have fairly short lifetimes, and are linked to tissue oxygenation and redox state. Moreover, tissue nitrite can serve as a significant extravascular pool of NO during brief periods of hypoxia. These findings vastly expand our understanding of the fate of NO in vivo and provide a framework for further exploration of the significance of nitrosative events in redox-sensing and signaling.

AUD $126.95

 This title is not held in stock & is ordered from suppliers, subject to availability.

View other Nathan Bryan titles like "Blood and Tissue Nitric Oxide Products"

Write a customer review of Blood and Tissue Nitric Oxide Products.

If you like this title please tell others:

tell others

post to your Facebook wall post on Twitter post on Digg recommend to Stumbleupon bookmark on Delicious RSS feed send to a friend

Australian BookShop
Australian Bookshop. Established 2003
Shopping Cart Customer Support

International Online Store
of Inspiration
we ship everywhere
Australia Post
Australia Wide