Characterization of Hyperpolarized Xe-129 NMR Spectra
by Mihai Gherase (9783639170375)

Characterization of Hyperpolarized Xe-129 NMR Spectra
 

Mihai Gherase


Release Date: 01 July 2009
Format: Paperback
Pages: 100
Category: Physics
Publisher: VDM Verlag
ISBN: 9783639170375
ISBN-10: 3639170377



This book describes the modeling and experimental effort in trying to use hyperpolarized Xe-129 (H-Xe) dissolved in Perfluorooctyl Bromide (PFOB) emulsions as an Nuclear Magnetic Resonance (NMR) contrast agent for cancer detection. H-Xe dissolved in PFOB emulsions stabilized with egg-yolk phospholipid (EYP) has been suggested as a possible in vivo NMR contrast agent. A two-compartment radial diffusive exchange model based on the generalized Bloch equations was developed. The model was used to investigate the NMR spectra of H-Xe dissolved in PFOB emulsions. The permeability of the EYP membrane was estimated by fitting the linewidths of the experimental NMR spectra with the modeled spectra linewidths. The experiments also showed that the linewidths of the NMR spectra of H-Xe in PFOB emulsions depend on the PFOB concentration because of the H-Xe diffusive exchange. Bulk water flow measurements were demonstrated by dynamic acquisition of H-Xe NMR spectra while the bolus formed of H-Xe gas in PFOB emulsions diluted during the passage through a coil.

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