Drosophila Melanogaster - Biosensors of Atmospheric Oxidative Stress
by Malinda Wilson (9783639130621)

Drosophila Melanogaster - Biosensors of Atmospheric Oxidative Stress

Malinda Wilson

Release Date: 01 March 2009
Format: Paperback
Pages: 112
Category: Biochemistry
Publisher: VDM Verlag
ISBN: 9783639130621
ISBN-10: 3639130626

Studies of Drosophila melanogaster have led to molecular insights concerning biomolecular mechanisms of biology and disease including development, differentiation, cancer and aging. Wild-type Drosophila, unlike vertebrate mammals, selectively retains gamma-tocopherol over alpha- tocopherol. Urate-deficient Drosophila compared to wild-type had similar levels of glutathione but only 50% of the ascorbate levels. Dietary supplementation with ascorbate dramatically increased its level while chemically-defined diets led to rapid depletion of ascorbate in both strains. It is concluded that Drosophila do not synthesize ascorbate, and in this respect are similar to humans. Wild-type and urate-deficient Drosophila were continuously exposed to ozone. Exposure of Drosophila to 2 ppm ozone/24hrs/day unmasked a marked sensitivity phenotype of urate-deficient Drosophila. Studies revealed that ascorbate supplementation decreased ozone-induced toxicity in Drosophila. Collectively, these data reveal the usefulness of Drosophila as a model organism for studying micronutrient antioxidants and their interrelationship with ozone-induced toxicity.

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