Effect of Antioxidants Grafting on the Hemocompatibility of HD
by Fu-Chen Kung (9783639159042)

Effect of Antioxidants Grafting on the Hemocompatibility of HD
 

Fu-Chen Kung


Release Date: 01 May 2009
Format: Paperback
Pages: 108
Category: Engineering
Publisher: VDM Verlag
ISBN: 9783639159042
ISBN-10: 3639159047



In this study, hollow fiber membrane (PAN,CA and PSF) was hydrolyzed and grafted with antioxidants such as conjugated linoleic acid (CLA)or heparin. The effects of antioxidants grafting on the blood coagulation, platelet aggregation, and oxidative stress were evaluated using human blood. The complete blood count (CBe and coagulation time (CT) was evaluated in vitro for the hemocompatibility. Furthermore, the removal of bacterial endotoxin (lipopolysaccharide, LPS) by antioxidant-bonding membrane was measured with ELISA. In addition, the production of reactive oxygen species (ROS) was measured by chemiluminescence (CL) method to evaluate the oxidative stress. In vitro evaluation was carried out using mini- hemodialyzer circulating with fresh porcine whole blood to simulating kidney therapy. The dialysis performance and hemocompatibility were estimated. These results suggest that a antioxidant-grafting membrane could offer protection for patients against oxidative stress and would be helpful for reducing the dosage of anticoagulant during hemodialysis.

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