Immune Synapses
by Takashi Saito (9783642038570)

Immune Synapses
Takashi Saito
Release Date: 14 December 2009
Format: Hardback
Pages: 255
Category: Immunology
Publisher: Springer
ISBN: 9783642038570
ISBN-10: 3642038573

Unknown details regarding the quantitative and qualitative aspects of the intercellular communication and viral transmission processes are examined in this complex review. Diverse topics are discussed which remain part of an intense debate.

While the importance of the immune synapse as a dynamic cell junction that regulates intercellular communication and viral transmission is universally recognized, many of quantitative and qualitative details remain unsettled. The plasticity of this cell junction has to accommodate many very different binding partners and control the fate of interacting cells. It is likely that developmental changes in the state of the T cells or the APCs can impact the structure of the synapse. It is hoped that uncovering the ordered molecular rearrangement at the membrane will provide the long sought after clues for the remarkable functional sensitivity of T lymphocytes. These dynamic molecular interactions may eventually explain how engagement of the same TCR can generate different outcomes that resolve the immune challenges. The reviews in this issue present a broad slice of the many diverse topics that are currently intensely debated.

Table of Contents:
Preface.- The immune synapse: a localized gateway to regulated immunity.- Insights into function of the immunological synapse from studies with supported planar bilayers.- Immunological synapses within context: Patterns of cell-cell communication and their application in T-T interactions.- Molecular and cellular dynamics at the early stages of antigen encounter: The B cell immunological synapse.- Inhibitory and regulatory immune synapses.- The immunological synapse, TCR microclusters, and T cell activation.- Signaling amplification at the immunological synapse.- - A conformation-induced oligomerization model for B cell receptor microclustering and signaling.- Co-receptors and recognition of self at the immunological synapse.- Vesicle traffic to the immunological synapse. A multifunctional process targeted by lymphotropic viruses.- Plasticity of immunological synapses.- APC, T cells and the immune synapse.- Subject index

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