Interactions Between Membrane Transporters and Phospholipids
by Pierre Hakizimana (9783639136708)

Interactions Between Membrane Transporters and Phospholipids

Pierre Hakizimana

Release Date: 01 March 2009
Format: Paperback
Pages: 92
Category: Biophysics
Publisher: VDM Verlag
ISBN: 9783639136708
ISBN-10: 3639136705

Highly solved crystal structures and a wealth of biochemical data are now available for an increasing number of membrane proteins. However, the question of how lipid molecules interact with integral membrane proteins and regulate their structure and function in biological membranes remains unsatisfactorily addressed. This book discusses the functional mechanisms of membrane proteins in general and the effect of the surrounding lipidic environment, in the context of recent developments in the field. Recent experimental investigations on the proton gradient-driven multidrug transporter LmrP are also discussed. Using this membrane protein as a model, we demonstrated that the protein structure and function was depending on the phosphatidylethanolamine (PE) headgroup. We then showed that a negatively charged residue, Asp68, could participate in the interaction with PE and that such interaction is required for proper activity and structure of the protein. Because Asp-68 belongs to a highly conserved motif of the Major Facilitator Superfamily (MFS), this interaction might be a general feature of these transporters that is involved in proton gradient sensing and lipid dependence.

AUD $95.95

 This title is not held in stock & is ordered from suppliers, subject to availability.

Write a customer review of Interactions Between Membrane Transporters and Phospholipids.

If you like this title please tell others:

tell others

post to your Facebook wall post on Twitter post on Digg recommend to Stumbleupon bookmark on Delicious RSS feed send to a friend

Australian BookShop
Australian Bookshop. Established 2003
Shopping Cart Customer Support

International Online Store
of Inspiration
we ship everywhere
Australia Post
Australia Wide