The Role of Uptake Transporters in Nose to Brain Dopamine Transport
by Nagendra Chemuturi (9783639114782)

The Role of Uptake Transporters in Nose to Brain Dopamine Transport
 

Nagendra Chemuturi


Release Date: 10 December 1010
Format: Paperback
Pages: 224
Category: Pharmacology
Publisher: VDM Verlag
ISBN: 9783639114782
ISBN-10: 3639114787



Dopamine, involved in the etiology of CNS related disorders such as Parkinson's disease, shows poor CNS disposition following oral and IV administration due to its extensive metabolism in the GI tract and poor permeation of the blood brain barrier. However, enhanced CNS uptake of dopamine was observed following intranasal administration. Western blotting and microscopy studies revealed the expression and presence of Dopamine Transporter (DAT) and Organic Cation Transporter-2 (OCT-2) in the nasal mucosa. Bi-directional transport studies demonstrated the role of both transporters in nasal mucosal dopamine transport. Taken together, these studies demonstrated the important role of both DAT and OCT-2 in dopamine uptake across the nasal mucosa. Nasal mucosal metabolism, which was also studied, of dopamine was small. So, nasal mucosal metabolism was not significant and does not limit nasal mucosal permeability of dopamine. The evidence from these studies suggests that enhanced CNS disposition of dopamine following nasal delivery is the result of carrier-mediated transport and is not significantly limited by nasal mucosal metabolism.

AUD $168.95

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